Laura Di Taranti, MD
Most patients who undergo intubation will receive some sort of post-intubation sedative. In the ICU, over-sedation is common, and early deep sedation is associated with worse outcomes in mechanically ventilated patients – specifically, higher mortality. Does the choice of sedative affect mortality?
A 55 year old patient presents via EMS reporting a large ingestion of his home oral phenytoin. As you go to evaluate the patient, you consider the clinical manifestations and possible complications of a phenytoin overdose. Is this a serious overdose? Is there a high potential for decompensation and the dreaded tox "seizure/coma/death" triad? Are there effective antidotes? Good thing you read this article!