Think Fast.....Sarin gas!

Think Fast, Sarin Gas

  • Clear, colorless liquid that can be absorbed by inhalation, ingestion, skin, or eye contact. A small volume can be lethal within minutes 
  • Organophosphorus compound that inhibits acetylcholinesterase resulting in increased acetylcholine at neuromuscular junctions
    • Muscarinic effects: SLUDGE (salivation, lacrimation, urination, defecation, GI distress, emesis), miosis
    • Nicotinic effects: initial fasciculations, eventual paralysis
    • CNS effects: anxiety, cardiopulmonary depression, seizure, coma
  • Protect yourself and your staff, ensure decontamination prior to treatment
  • Treating the patient:
    • Atropine, muscarinic receptor blocker: Reverses SLUDGE
    • Pralidoxime (2-PAM), removes cholinesterase inhibitor from cholinesterase: Reverses respiratory muscle paralysis
    • Diazepam, for treatment and prevention of seizures
    • Early intubation given respiratory failure is the primary cause of death