Digoxin

Back to Basics: Digoxin Toxicity Pearls

  • Digitalis inactivates the Na-K-ATPase pump to increase intracellular calcium and extracellular potassium, causing + inoptropy, hence usage in CHF patients
  • Dig also increases vagal tone and decreases conduction through the AV node, hence usage in atrial fibrillation. In toxic doses, this is what leads to bradydysrhythmias

Toxicity can either be Acute or Chronic:

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