The Core of Asthma Management: Anticholinergic Agents

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Anticholinergic Agents:

 

Mechanism of Action:

  • Competitively antagonizes acetylcholine at the postganglionic junction between the parasympathetic nerve terminal and effector cell
  • Blocks vagal-mediated bronchoconstriction of larger airways

 

Side Effects: Dry mouth, thirst, difficulty swallowing, tachycardia, restlessness, irritability, urinary retention, blurry vision, increased intraocular pressure

Aerosolized delivery via MDI or nebulizer
Has a synergistic effect when combined with short-acting beta agonists

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