Thu, 04/30/2020 - 5:44am
- Logistic regression for factors associated with development of pneumonia showed that prophylactic antibiotics were associated with reduced incidence of pneumonia.
- OR = 0.09; 95% CI (0.06 - 0.14); p = <0.001
- Logistic regression for factors associated with good functional outcome: use of prophylactic antibiotics was removed from the model before final run because of lack of influence on the outcome.
- Incidence of early VAP (within 7 days of hospitalization) lower in intervention group.
- HR = 0.53; 95% CI (0.31 - 0.92); p = 0.03
- No difference in number of ventilator free days or mortality at day 28 (secondary outcomes).
- No deaths attributable to VAP or sepsis.
- Gagnon, et. al. Prophylactic antibiotics are associated with a lower incidence of pneumonia in cardiac arrest survivors treated with targeted temperature management. Resuscitation. 2015; 92:154-159.
- Cariou, et. al. Prevention of early ventilator-associated pneumonia after cardiac arrest. New England Journal of Medicine. 2019; 381:1831-1842.