Toxicology

Back to Basics: Digoxin Toxicity Pearls

  • Digitalis inactivates the Na-K-ATPase pump to increase intracellular calcium and extracellular potassium, causing + inoptropy, hence usage in CHF patients
  • Dig also increases vagal tone and decreases conduction through the AV node, hence usage in atrial fibrillation. In toxic doses, this is what leads to bradydysrhythmias

Toxicity can either be Acute or Chronic:

Tags: 
Topic: 
Category (Day): 

#EMconf: Serotonin Syndrome

To wrap up our toxicology module, Dr. Sumaya Mekkaoui reviewed serotonin syndrome.  This can be a challenging diagnosis to make and is often misinterpreted as other psychiatric or medical syndrome.  Look ahead for a quick review on the  clinical presentation, drugs implicated in serotonin syndrome, and comparing/contrasting similar toxidromes.  

Topic: 
Category (Day): 

#EMconf: The (Dis)Utility of the Urine Drug Screen

The Urine Drug Screen (UDS) is a commonly used test in the emergency department, however there are many shortcomings that limit its diagnostic utility. The Urine Drug Screen is exactly that – a SCREENing and not a confirmatory test!  This week Dr. Lauren Murphy educated us on: 1) the potential false positives and negatives of the UDAS and 2) the detection times that drug metabolites are at a concentration in the urine to trigger a positive result (cutoff value).  Read ahead for the reference tables!    

Topic: 
Category (Day): 

Methemo...whaa?!?!: Basics of Methemoglobinemia

Interesting case of a cyanotic patient lately? Looking for good questions to pimp medical students or residents with (had an attending in residency who always loved to ask about way he only recommended pyridium for use for a couple of days for UTI symptoms)? Studying for boards? Below are some teaching points on methemoglobinemia.

Topic: 
Category (Day): 

Back to the Basics: Poison Ivy (Toxicodendron) Dermatitis

As the weather becomes nicer, more people are venturing outside to work on their yards, hike and just take in the sun - and hence, more people are becoming exposed to poison ivy, oak, and sumac.  Learn the basic management for toxicodendron dermatitis. 

Category (Day): 

Pages