Wednesday Image Review

What’s the Diagnosis? By Dr. Christine Hill

A 76-year-old male with a history of coronary artery disease presents with 3 months of abdominal pain. Patient first experienced nausea, vomiting, diarrhea, chills, and severe right lower quadrant abdominal pain approximately 3 months ago. Patient states the pain improved after several days of rest, a bland diet, and hydration. However, patient reported continued decreased appetite and weight loss of 15-20 pounds over the intervening months. The pain recurred approximately one month ago and did not improve with rest prompting patient to see his primary care physician. Patient was placed on oral amoxicillin–clavulanate and instructed to get a CT scan of the abdomen and pelvis. Patient presented to the emergency department following the CT. Vitals include BP 122/69, HR 60, SpO2 98% on RA, T 97.8F. Patient is well appearing with mild tenderness to palpation in the right lower quadrant.

An ultrasound is performed and shown below. What’s the diagnosis? How is the ultrasound performed? What else should you be considering given this patient’s history?

Answer: Appendicitis

Appendicitis Ultrasound:

Technique

  • Probe – Linear probe often works best. Can consider curvilinear probe in those with larger body habitus.
  • 1) Ask patient to point area of maximal tenderness and place linear probe on this area
  • 2) Apply steady but gradually increasing pressure in this area to displace bowel gas and enable visualization
  • 3) Appendix is typically anterior to psoas and iliac vessels and is a blind tubular structure that has no peristalsis
  • 4) If not visualized over area of maximal tenderness can track up and down along iliac vessels to look for appendix

Pathologic findings

  • 1) Dilation > 6 mm in transverse diameter
  • 2) Non-compressible
  • 3) May have surrounding edema and fecalith within the appendix

Appendicitis Ultrasound Pearls:

  • Appendix can be hard to visualize due to body habitus, bowel gas, or because it is retrocecal. Tips to improve visualization:
    • Have patient place right leg crossed over left
    • Roll patient into left lateral decubitus
  • Appendix can be hard to differentiate from terminal ileum
    • Terminal ileum does not have a blind ending
    • Terminal ileum will show peristalsis
  • Always make sure to visualize the blind ending of the appendix
  • Ultrasound “Rules In” appendicitis!

Patient ultimately taken to OR by surgery where appendix was removed and sent to pathology. Given patients presentation of chronic appendicitis couple with weight loss there was concern for appendiceal cancer. Pathology has not returned at this time.

Appendiceal Cancer Facts:

  • Cancer of the appendix is observed in <2% of appendiceal specimens
  • Most patients are asymptomatic but in those who experience symptoms 30% present with acute appendicitis
  • History that should raise suspicion for appendiceal cancer include
    • Appendicitis in a patient >50 yrs of age
    • Chronic symptoms of appendicitis
    • Weight loss and anorexia

References:

https://coreultrasound.com/appendicitis/

Uya, A., & Chaiaza, H. (2021, June 24). Appendicitis. ACEP Symbol. https://www.acep.org/sonoguide/advanced/appendicitis

Osueni A, Chowdhury YS. Appendix Cancer. [Updated 2023 Aug 7]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK555943/

Friday Board Review

From the Archives: Acute Signs Board Review with Dr. Christine Collins

A 50 year old male presents with 4 weeks of diarrhea and associated abdominal pain described as cramping. He reports multiple episodes of pale, loose and malodorous stools daily. He recently went fishing. His vitals are as followed: 70 bpm, BP: 125/80, RR 18, PO2: 98%. Temp 37.2. What vitamin deficiency would you worry about in this patient?

A. Vitamin

B. Niacin

C. Vitamin C

D. Riboflavin

Answer: Riboflavin

This patient is presenting with signs and symptoms consistent with giardiasis. Patients can have malabsorption and steatorrhea, and chronic infection can result in deficiency of fat soluble vitamins A, D, E, and K.  Malabsorption can also lead to deficiency in Vitamin B12 and folate.

Giardiasis is the most common cause of parasitic diarrheal infection in the US and is transmitted by fecal-oral route. It is associated with streams and daycares. Classic symptoms include, colicky abdominal pain and pale, loose, malodorous stools. Treatment is metronidazole.  

References: 

Singh KD, Bhasin DK, Rana SV, et al. Effect of Giardia lamblia on duodenal disaccharidase levels in humans. Trop Gastroenterol 2000; 21:174.

Bjoernsen, L. P., & Ebinger, A. (2016). Chapter 159 Foodborne and Waterborne Diseases In Tintinalli’s Emergency Medicine: A Comprehensive Study Guide (8th ed). New York, NY: McGraw-Hill Education.

Wednesday Image Review

From the Archives: What’s the Diagnosis? By Dr. Loran Hatch

A 62 year old male presents to the ED with 1 week of abdominal distension with associated nausea and vomiting. He has had only 2 small bowel movements in the last week. He denies abdominal pain. On exam, his abdomen is distended and rigid. An obstruction series is obtained and shown below. What’s the diagnosis?

Answer: multiple air-fluid levels concerning for obstruction

  • CT A/P obtained (shown below) – diagnosis of Large bowel obstruction
  • Most common cause of large bowel obstruction = neoplasm/mass
    • Other causes: diverticulitis, sigmoid or cecal volvulus
    • Other uncommon causes: adhesions, hernias, IBS, fecal impaction, intraluminal FB, intussusception
  • LBO are less common than SBO
  • Presenting sypmtoms: abdominal pain/distension, constipation
  • CT A/P w/ IV contrast is imaging modality of choice
  • Most require surgery
  • Ogilvie Syndrome: acute colonic psuedo-obstruction due to loss of sympathetic innervation of colon (no actual mechanical obstruction)
    • Usually seen in severely ill patients with multiple comorbidities
    • CT shows marked dilatation of the large bowel without any evidence of a marked transition point or obstructing lesion

References:
Jaffe T, Thompson WM. Large-Bowel Obstruction in the Adult: Classic radiographic and CT findings, etiology and mimics. Radiology. 2015 June;275(3):651-63.

Price TG, Orthober RJ. Bowel Obstruction. Tintinalli’s Emergency Medicine: A Comprehensive Study Guide, 8e Eds. Judith E. Tintinalli, et al. New York, NY: McGraw-Hill, 2016, pg 538-41

Monday Back to Basics & Pharmacology

From the Archives: Peptic Ulcer Disease and Gastritis by Dr. Angela Ugorets and Dr. Karen O’Brien

Peptic Ulcer Disease

Chronic illness, recurrent ulcers in stomach and duodenum most commonly due to H. Pylori and NSAIDs. 10% people in the western world will have this in their lifetime.

Symptoms:

  • Burning, gnawing, achy, “empty, hungry” epigastric pain
  • Relieved by ingestion of food (usually), milk, antacids (buffers/dilutes gastric acid)
  • Worsens after gastric emptying, classically the pain awakens patients at night
  • Chronic ulcers can be asymptomatic or cause painless GI bleeding
  • NOT (usually) related to PUD: pain after eating, nausea, belching
  • “Alarm features” for suspicion of cancer –> need more emergent endoscopy: >50 yo, weight loss, persistent vomiting, dysphagia/odynophagia, GIB, abdominal mass, lymphadenopathy, Family hx

Physical Exam: For uncomplicated PUD, expect benign physical exam +/- epigastric tenderness (not sensitive or specific). VS should be normal. 

Workup: Generally includes CBC to rule out anemia from chronic GIB. Consider LFT, lipase, EKG, trop, upright CXR, RUQ US to rule out other etiologist that may present similarly with epigastric pain if indicated. Gold standard for diagnosis is endoscopy.

Treatment

  • Stop NSAIDs 
  • Proton pump inhibitors: decrease acid secretion from gastric parietal cells, irreversibly bind with H+K+ATPase (proton pump).
    • Example: omeprazole, pantoprazole.
    • Heal ulcers faster than any other tx. 
  • H2 receptor antagonists: Inhibit action of histamine on H2 receptor on gastric parietal cells
    • Example: famotidine, ranitidine.
    • Dose should be adjusted for patients in renal failure. 
  • Sucralfate: covers ulcer crater, protects it and allows healing, but doesn’t relieve pain as well 
  • Antacids: buffer gastric acid. Use for breakthrough pain. (Ex: Mylanta, Rolaids, Tums, etc) 

Dispo: As long as uncomplicated (no bleed, obstruction, perforation, etc), can be discharged from ED with Rx for meds above and referral to PCP or GI.

Gastritis

  • Not the same as PUD
  • Acute or chronic inflammation of gastric mucosa (not discrete ulcers) 

Causes: ischemia, toxic effects of NSAIDs, steroids, bile, alcohol, H. Pylori, autoimmune processes that destroy gastric parietal cells 

Exam: epigastric pain, N/V. Often presents with GIB: hematemesis vs chronic anemia vs melena 

References:

Fashner J, Gitu AC. Diagnosis and Treatment of Peptic Ulcer Disease and H. pylori Infection. Am Fam Physician. 2015 Feb 15;91(4):236-42. PMID: 25955624.

Malfertheiner P, Chan FK, McColl KE. Peptic ulcer disease. Lancet. 2009 Oct 24;374(9699):1449-61. doi: 10.1016/S0140-6736(09)60938-7. Epub 2009 Aug 13. PMID: 19683340.

Friday Board Review

Toxicology Board Review with Dr. Edward Guo

A 45 year old male with a history of autism, depression, and epilepsy presents for an overdose. He was found in his bedroom obtunded by family with empty pill bottles. His medication list includes valproic acid and fluoxetine. He was intubated by EMS for airway protection. His vital signs include Temp 98.0F, HR 108, BP 100/60, RR 16, SpO2 99% on 40% FiO2. On exam, he has a GCS of E1 V1T M4 with minimal sedation. Pupils are equal and reactive to light. There is no rigidity or clonus. Labs are notable for elevated LFTs and ammonia. Which of the following medications should be used for the treatment of this patient’s suspected overdose?

A: Cyproheptidine

B: Levo-carnitine

C: Meropenem

D: B & C

Answer: B & C (Levo-carnitine & Meropenem)

This patient’s presentation is consistent with valproic acid overdose. The most common exam finding is CNS depression which can range from drowsiness to coma. Serotonin syndrome classically presents with hyperthermia and clonus. Treatment of serotonin syndrome typically includes supportive care with benzodiazepines and cyproheptadine with consultation of a toxicologist. Treatment of valproic acid toxicity includes GI decontamination and levo-carnitine as it can increase metabolism of valproic acid, hasten resolution of coma, and prevent hepatic dysfunction. Newer studies have shown that concomitant use of carbapenems (specifically meropenem) with valproic acid causes drug-drug interactions that lead to decreased serum valproic acid concentrations. Dialysis can be considered for severe overdoses with hemodynamic instability or acidosis that does not respond to initial therapy.

References:

LoVecchio F. Anticonvulsants. In: Tintinalli JE, Ma O, Yealy DM, Meckler GD, Stapczynski J, Cline DM, Thomas SH. eds. Tintinalli’s Emergency Medicine: A Comprehensive Study Guide, 9e. McGraw Hill; 2020. 

Al-Quteimat O, Laila A. Valproate Interaction With Carbapenems: Review and Recommendations. Hosp Pharm. 2020;55(3):181-187. doi:10.1177/0018578719831974Al-Quteimat, O., & Laila, A. (2020). Valproate Interaction With Carbapenems: Review and Recommendations. Hospital pharmacy55(3), 181–187. https://doi.org/10.1177/0018578719831974

Special shoutout to our ED pharmacists that educated us on this topic!

Wednesday Image Review

What’s the Diagnosis? By Dr. Carlos Cevallos

Case: A 60 year old female with a past medical history of a left hip replacement presents with a chief complaint of left hip pain after a fall. Since the fall she has been unable to move her hip and on exam the left leg is visibly shortened, adducted, and internally rotated, otherwise the patient is neurovascularly intact. X-ray reveals the image below. What’s the diagnosis?

Answer: Posterior Hip Dislocation

Case Continued: Under procedural sedation with keto-fol the hip was reduced successfully using the Captain Morgan technique as demonstrated in post-reduction XRs below. The patient was then placed in a knee immobilizer and discharged with an abduction pillow and orthopedic follow up.

  • Over 90% of hip dislocations are posterior
  • Up to 10% of prosthetic hips undergo dislocation with the vast majority being posterior
  • Native hip dislocations are an orthopedic emergency and should be reduced as soon as possible!
    • The risk of avascular necrosis increases from <10% to about 25%  when reduction is extended from 10 hours to 15 hours
    • Prosthetic hip dislocation is not as time sensitive as there is no blood flow to the joint, thus no risk of avascular necrosis.
    • Sciatic nerve injury can occur in both native and prosthetic posterior hip dislocations
  • There are many different reduction techniques including but not limited to:
  • A CT should be obtained post-reduction of native hips to rule out fractures/loose debris

Resources:

https://www.merckmanuals.com/professional/injuries-poisoning/dislocations/hip-dislocations#v35074190

Tintinalli’s Emergency Medicine Cases A comprehensive Study Guide 9th Edition, Judith Tintinalli

Tuesday Advanced Cases & Procedure Pearls

Electrical Storm by Dr. Edward Guo

HPI: 

  • A 58 year old male with a past medical history of CAD s/p PCI, cardiomyopathy with EF 30-35% c/b VF arrest s/p ICD presents via EMS as a STEMI alert. 
  • While en route, patient had episode of VT on the cardiac monitor and was defibrillated by the ICD almost immediately, returning to narrow complex rhythm. 
  • He remains neurologically intact and states that 1 hour ago he started having crushing substernal chest pain and feels like he is going to die.  

Physical Exam:

Vitals: BP 84/40, HR 39, RR 20, SpO2 94%

  • GCS 15, moves all extremities equally
  • Appears pale, diaphoretic, in obvious extremis
  • Bradycardic with cool extremities
  • Trace pitting edema in bilateral lower extremities

EKG interpretation: Junctional rhythm with PVCs in pattern of bigeminy. Inferior STEMI with reciprocal ST segment depressions in lateral leads. 

Case continued:

  • Patient was given 324mg aspirin en route by EMS. Additionally given 300 mg amiodarone bolus, 4000 U heparin bolus, and 500 cc LR bolus upon arrival to ED.
  • During initial resuscitation, cardiac rhythm converts to VT and patient is immediately defibrillated by ICD with ROSC and remains neurologically intact. 
  • Patient persistently hypotensive and norepinephrine infusion is initiated to MAP > 65.
  • Patient experiences another episode of VT and is again immediately defibrillated by ICD with ROSC and remains neurologically intact. 
  • Decision is made in junction with cardiology and interventional cardiology to transport patient immediately to catheterization lab. During the procedure, the patient continues to have multiple episodes of VT and VFib and undergoes general anesthesia and is intubated. The angiogram demonstrates a 100% occlusion of the proximal RCA. The patient recovers in the CCU and was discharged on hospital day 5.

Pearls:

  • Electrical storm is defined by 3 or more sustained episodes of VT, VFib, or appropriate shocks from an ICD within 24 hours. 
  • Initial management adheres to ACLS protocol with strict attention to airway, breathing, and circulation.
    • Medications include epinephrine, amiodarone, and lidocaine
  • Consider the following for refractory VT/VF (electrical storm):

References:

Eifling M, Razavi M, Massumi A. The evaluation and management of electrical storm. Tex Heart Inst J. 2011;38(2):111-121.

Driver BE, Debaty G, Plummer DW, Smith SW. Use of esmolol after failure of standard cardiopulmonary resuscitation to treat patients with refractory ventricular fibrillation. Resuscitation. 2014;85(10):1337-1341. doi:10.1016/j.resuscitation.2014.06.032

Friday Board Review

Pediatrics Board Review with Dr. Edward Guo

A 13 year old male presents to the emergency department for 2 days of abdominal pain and diarrhea. He has no past medical or surgical history other than a tooth extraction for which he recently completed a week of clindamycin. The abdominal pain is generalized and associated with greater than 5 episodes of watery diarrhea daily. He denies any vomiting or recent travel. Vitals signs are: HR 120, BP 108/60, T 38.3 C, RR 20, SpO2 99% RA. On exam, he is tired but non-toxic appearing and not in acute distress. Mucous membranes are dry, and his cap refill is between 2 to 3 seconds. His abdomen is minimally tender to palpation diffusely with no guarding or rigidity. IV access is obtained and fluid resuscitation is started. What is the appropriate antibiotic treatment for this patient’s suspected condition?

A: IV vancomycin and cefepime

B: PO metronidazole

C: PO vancomycin

D: PO vancomycin and IV metronidazole

Answer: PO metronidazole

This patient’s fever, abdominal pain, and profuse diarrhea in the setting of recent antibiotic use is worrisome for Clostridium difficile (C. Diff) infection. Oral metronidazole is the treatment of choice in mild to moderate cases of pediatric C. Diff colitis. It is first-line due to being less expensive than vancomycin and avoids the potential risk of developing vancomycin-resistant enterococci. IV vancomycin and cefepime are broad spectrum agents commonly used in sepsis but are not preferred for suspected C. Diff colitis. In addition, the combination lacks anaerobic coverage for gastrointestinal infections. PO vancomycin with or without IV metronidazole is reserved for recurrent or severe infection which includes hypotension, ileus, or inability to tolerate PO antibiotics. 

Pediatric Clostridium Difficile Colitis Treatment
All patientsFluid resuscitation and electrolyte repletion
Discontinue offending antimicrobial agents if possible
Mild to moderate diseasePO metronidazole
Severe diseasePO or rectal vancomycin + IV metronidazole

References:

Freedman S.B., & Thull-Freedman J (2020). Vomiting, diarrhea, and dehydration in infants and children. Tintinalli J.E., & Ma O, & Yealy D.M., & Meckler G.D., & Stapczynski J, & Cline D.M., & Thomas S.H.(Eds.), Tintinalli’s Emergency Medicine: A Comprehensive Study Guide, 9e. McGraw Hill.

Wednesday Image Review

From the Archives: What’s the Diagnosis? By Dr. Becca Fieles

A 30 year old female with a history of IV drug use presents with 2 weeks of progressively worsening right sided pleuritic chest pain, productive cough, and shortness of breath.  A chest x-ray is shown below. What’s the diagnosis?

Answer: Cavitary lesion with air-fluid level consistent with abscess from septic emboli secondary to infective endocarditis

Etiology: Bacteria laden clots from right sided bacterial endocarditis, septic thrombophlebitis, periodontal, and central venous catheter infections. In IVDU, the tricuspid valve is most commonly involved with the most common pathogen being Staph aureus

Presentation: Pleuritic chest pain, cough, fever, hemoptysis

Differential for lung abscesses: Septic emboli, Tuberculosis, Aspergillosis, Granulomatosis with Polyangitis, Sarcoidosis, malignancy

Diagnosis: Chest x-ray, CT chest, blood cultures, echocardiogram

Treatment: Typically 2-8 weeks of IV antibiotics with possible abscess drainage +/- heart valve replacement

References:

Stawicki SP, Firstenberg MS, Lyaker MR, et al. Septic embolism in the intensive care unit. Int JCrit Illn Inj Sci. 2013;3(1):58-63. doi:10.4103/2229-5151.109423

Parkar AP, Kandiah P. Differential Diagnosis of Cavitary Lung Lesions. J Belg Soc Radiol.2016;100(1):100. Published 2016 Nov 19. doi:10.5334/jbr-btr.1202

Friday Board Review

Internal Medicine Board Review with Dr. Edward Guo

A 60 year old male with a history of poorly controlled type 2 diabetes, hypertension, and hyperlipidemia presents for right foot pain. He noticed a few weeks ago that he developed a wound on the sole of his right foot which hurts with pressure. He denies any injury to the area or fevers. Vitals are within normal limits. Exam is notable for a shallow based ulcer with clean margins and no active drainage on the sole of his right foot. Which of the following positive physical exam findings, laboratory test, or imaging study has the highest positive likelihood ratio for osteomyelitis in this patient?

A: ESR > 70

B: MRI

C: probing to bone

D: ulcer area > 2 cm2

Answer: ESR > 70

This patient is presenting with a diabetic foot ulcer, a common complication of poorly controlled diabetes. While many physical exam features such as fever, pain, or purulence may be suggestive of osteomyelitis, an accurate diagnosis remains a challenge especially with co-existing diabetic neuropathy and blunted immune responses from diabetes. Although it is a non-specific marker of inflammation, an ESR > 70 mm/h has the highest likelihood ratio of osteomyelitis compared to other exam, laboratory, and imaging investigations as shown in the table below. This emphasizes the sensitivity and diagnostic utility of obtaining an ESR level in the emergency department to investigate for osteomyelitis in patients with diabetic foot ulcers. The gold standard test to diagnose osteomyelitis is a bone biopsy.

Positive FindingPositive LR (95% CI)Negative LR (95% CI)
Ulcer area > 2 cm²7.2 (1.1 – 49)0.48 (0.31 – 0.76)
“Probe to bone”6.4 (3.6 – 11)0.39 (0.20 – 0.76)
ESR > 70 mm/h11 (1.6 – 79)0.34 (0.06 – 1.90)
Plain radiograph2.3 (1.6 – 3.3)0.63 (0.51 – 0.78)
MRI3.8 (2.5 – 5.8)0.14 (0.08 – 0.26)
Table adapted from Tintinalli’s Emergency Medicine: A Comprehensive Study Guide, 9e Table 224-2

References:

Jalili M, Niroomand M. Type 2 Diabetes Mellitus. In: Tintinalli JE, Ma O, Yealy DM, Meckler GD, Stapczynski J, Cline DM, Thomas SH. eds. Tintinalli’s Emergency Medicine: A Comprehensive Study Guide, 9e. McGraw Hill; 2020.

Mandell  JC, Khurana  B, Smith  JT, Czuczman  GJ, Ghazikhanian  V, Smith  SE: Osteomyelitis of the lower extremity: pathophysiology, imaging, and classification, with an emphasis on diabetic foot infection. Emerg Radiol 2017 Oct 20. doi: 10.1007/s10140-017-1564-9. [Epub ahead of print] [PubMed: 29058098]